LONG-TERM AND LATE-TERM EFFECTS OF TREATMENT IN SURVIVORS OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA: A SYSTEMATIC REVIEW

Athina Kavoura , Maria Moschovi, Ioannis Koutelekos, Afroditi Zartaloudi, Chrisoula Dafogianni, Maria Polikandrioti, Evangelos Dousis

Sunday, October 1, 2023

Publication year:

2023

Authors:

• Kavoura Athina, Nurse MSc(c), MSc in “General Pediatrics and Pediatric Subspecialties: Clinical Practice and Research”, Department of Medicine, National and Kapodistrian University of Athens, , Greece
• Moschovi Maria, Associate Professor, Department of Medicine, National and Kapodistrian University of Athens, Greece
• Koutelekos Ioannis, PhD, Associate Professor, Department of Nursing A',Technological Educational Institute of Athens
• Zartaloudi Afroditi, Lecturer, Department of Nursing, TEI of Athens
• Dafogianni Chrisoula, MSc in Applied Clinical Nursing, University of West Attica, Department of Nursing, Athens, Greece
• Polikandrioti Maria, Assistant Professor,Department of Nursing,Technological Educational Institute of Athens
• Dousis Evangelos, Assistant Professor, Department of Nursing, University of West Attika

Keywords index:

• Acute lymphoblastic leukemia
• survivors
• survivorship
• term effects
• late term effects
• pediatric nursing

Pages: 369-383

DOI: 10.5281/zenodo.13208461

Abstract:

Introduction: Treatment of childhood acute lymphoblastic leukemia (ALL) has long-lasting effects on survivors.The purpose of the study was to investigate the long-term and late-term effects of treatment in survivors of childhood ALL.Methodology: Systematic literature review using keywords: acute lymphoblastic leukemia, survivors, long effects, late effects, in international bibliographic databases (Medline, PubMed, Scopus) as well as synonyms and combinations of the terms. The PICOS procedure and the PRISMA methodology were used as evaluative criteria for the inclusion of articles in the study. The inclusion criteria for articles in the study were: to be research studies, published from 2019-2023, investigating the long-term effects of treatment in survivors of childhood ALL, published in English-language scientific journals;Results: Distant complications of ALL treatment in survivors include social adjustment, pregnancy problems, premature ocular aging, non-adherence to lifestyle guidelines, memory, spermatogenesis and premature ovarian failure disorders, anxiety, short stature and disorders of the urinary system, thyroid, hearing & skin problems, school performance, cardiovascular dysfunction, body weight, motor-sensory neuropathy, endocrinopathy.Conclusions: The long-term effects of treatment in survivors of childhood ALL are multiple and significant, and their more in-depth investigation will help highlight the factors associated with them and provide strong evidence for their prevention and treatment.